Travel to the red-rock canyon country of northern Arizona to learn about history and nature at Pipe Spring National Monument. As the Perseid Meteor Shower approaches, find ways you can enjoy the night sky. Follow the story of the race to ratification of the 19th Amendment to the Constitution, which was underway years ago. Discover opportunities for youth ages 35 and under to get involved in caring for our national parks.
Triggering of the complement cascade induces tumor cell lysis via complement-dependent cytotoxicity CDC and attracts and activates cytotoxic cells. It therefore represents an attractive mechanism for mAb in cancer immunotherapy development. The classical complement pathway is initiated by IgG molecules that have assembled into ordered hexamers after binding their Ag on the tumor cell surface. The requirements for CDC are further impacted by factors such as Ab epitope, valency, and affinity. Thus, mAb against well-validated solid tumor targets, such as the epidermal growth factor receptor EGFR that effectively induces complement activation and CDC, are highly sought after. The potency of complement activation by IgG Abs can be increased via several strategies. We identified single-point mutations in the Fc domain e.
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